Abstract: I. Introduction to the Pharmaceutical Purified Water Equipment System This pharmaceutical purified water equipment is based onGMPThe purified water equipment that meets the certification requirements is designed with an overall sanitary grade of all stainless steel. It adopts a two-stage reverse osmosis purified water treatment technology, effectively removing various salts and impurities in water. The produced water meets the purified water standards, with stable water quality, simple operation, low operating costs, environmental friendliness, and convenient maintenance. It can be used in medical applications...

I. Introduction to the Pharmaceutical Purified Water Equipment System

      This pharmaceutical purified water equipment is based onGMPThe purified water equipment that meets the certification requirements is designed with an overall sanitary grade of all stainless steel. It adopts a two-stage reverse osmosis purified water treatment technology, effectively removing various salts and impurities in water The water meets the standards of purified water. The water quality is stable, the operation is simple, the operating cost is low, it is environmentally friendly and green, and the maintenance is convenient. It can be used for medical equipment, pharmaceutical water, blood purification, large-volume parenteral solutions, biochemical product water, medical sterile water, oral liquid water, etc. The produced water can be further processed into sterile distilled water.

The pharmaceutical purified water equipment system adopts the following process flow

Raw water→Raw water booster pump→Quartz sand filter→Activated carbon filter→Water softener (still applicable in areas with high water hardness)→Security filter→Stage reverse osmosis →Pure water tank→Pure water booster pump→Stage reverse osmosis→Sterile purified water tank→Ozone generator→Purified water booster pump→Ozone generator→ Ultraviolet device→Microporous filter→Water usage points for purified water

Iii. System Solutions and Design Advantages of Pharmaceutical Purified Water Equipment

1.Pipeline system

1.1.The connection parts of the purified water system should be made by welding first, followed by clamping. The use of threaded connection methods is strictly prohibited.

1.2.The entire system adopts a one-sided welding and two-sided forming process. The water quality is classified into different grades and is divided into manual welding and automatic welding processes. Automatic welding is used when in contact with purified water. After welding, passivation treatment is carried out. Internal gauge mirror photos are provided along with the test report.

1.3.Filters, pressure gauges and conductivity probes in contact with the product waterROBoth the membrane housing and ultraviolet rays are connected by sanitary grade clamps.

1.4.The pipelines in contact with the purified water all meet the requirementsGMP3DThe requirement is that the rubber pad isPTPEWhen the diaphragm valve is installed horizontally, it is45The installation of the circulating pipeline is set as follows0.5Set the lower point of the slope as the discharge point.

1.5.Sampling points are set up respectively for each pressure section to facilitate water quality testing.

2,ROTechnical requirements for membrane housing and precision filters

2.1.The entire structure is seamless304Made of stainless steel pipe.

2.2.All interfaces are connected by sanitary grade clamps.

2.3.The pipeline setting can drain the concentrated water inside.

2.4.The pipelines in the purified water section are welded by automatic welding process, using German welding machines andGFSpecial pipe-cutting tools are used for compaction.

2.5.The precision filter is detachable and has a clean internal structure.

3.Functional description

3.1.Adopt Mitsubishi of JapanPLC+The touch screen fully automatic control mode, and all control circuits are24VVoltage.

3.2.The touch screen features process flow images, and there are dynamic monitoring images for each water pump, switch and liquid level.

3.3.It has an alarm recording function. If any abnormality occurs, it will issue an audible and visual alarm.

3.4.The automatic mode is one-click start, which is simple and convenient to operate.

3.5.The manual mode is equipped with management permissions, which are divided into two levels: engineer and operator management.

3.6.The water quality sections at all levels are set with the function of discharging qualified water and unqualified water to the previous section to ensure the stability of water quality.

3.7.To ensure that there are no dead corners in each section, if the secondary reverse osmosis and purified water tanks are full and no water is used at the terminal within two hours, with no change in the liquid level of the terminal water tank, the water will automatically circulate to the tap water tank, triggering the entire system to regenerate water and preventing the growth of water in the pipeline due to long-term inactivity.

3.8.The signal points of each water tank liquid level switch system, as well asRORinse. The startup and cycle times can be modified on the touch screen, and permission management can be set up.

4.2T/HPharmaceutical purified water equipment is installed on-site

4.1.The layout should be adequate, and the positions should be reasonably set up according to the on-site conditions, with convenient maintenance passages established.

4.2.The pipelines installed in the factory should be horizontal and vertical, looking elegant and decent.

4.3.Wires and cables should comply with national electrical standards.

4.4.The current factory pipelines are manually welded, and the cable trays are firm and reliable. Each bracket should be less than1.4MThe pipeline has a certain slope.

4.5.Welding samples should be taken and recorded every day. After each day's construction is completed, keep the place clean and tidy. Pipes should be sealed with strips to prevent foreign objects from entering the interior of the pipes.

5.Main configuration system

5.1."In line withGMPThe certification requirements are tailor-made for pharmaceutical enterprises. Kerui not only provides a stable and reliable set of equipment, but also offers certification system materials and solutions.

5.2.The system is made of all stainless steel, operates stably, is exquisite and beautiful, and is simple and convenient to operate.

5.3.It is equipped with a raw water tank and an intermediate water tank, and is fitted with a liquid level gauge device to prevent the equipment from being affected by unstable tap water pressure.

5.4.Equipped with a dedicated sterile water tank for purified water, pressure-type liquid level gauge, rotary spray cleaning and air breathing device.

5.5.It is equipped with a water tank inlet solenoid valve, which is more stable in performance than the conventional float ball inlet valve.

5.6.The dual-stage reverse osmosis system configuration is adopted to ensure the stable operation of the system to the greatest extent.

5.7.Equipped withPHRegulation and online detection system, USAMilton royMetering pump, regulationPHValue, preventionCO2 The influence on the water quality of the produced water.

5.8.It adopts imported Hydranautics low-pressure reverse osmosis, featuring high desalination rate, long service life, stable operation and reduced energy consumption20%.

5.9.Reverse osmosis is scientifically configured through membrane design software and on-site operation experience.

5.10.It is equipped with a dedicated concentrated water diaphragm regulating valve, which is easy to operate.

5.11.Equipped with ozone; Clean more thoroughly.

5.12.Equipped withUVUltraviolet rays and membrane filters prevent the impact on water quality.

5.13.It features multiple protection functions such as no water, low pressure, and overpressure at key pressure points.

5.14.The main electrical components are made of Schneider from France, ensuring quality and quantity, and are designed in accordance with relevant configurations.

Iv. Functions of Each Component in the Pharmaceutical Purified Water Equipment System

1.Raw water tank, function: Store the raw water of the system, regulate the incoming water, and also play a certain sedimentation role for impurities in the incoming water.

2.Sand filter, function: Initially remove sand, impurities, suspended solids and other particles from water to reduce water turbidity.

3.Carbon filter, function: Utilizes the adsorption principle of carbon to adsorb discoloration, odor, residual chlorine and other substances in water.

5.Security filter, function: Prevent large particle impurities from entering the reverse osmosis membrane, causing damage to the membrane, and protect the reverse osmosis membrane.

6.Reverse osmosis main unit, function: Mainly to achieve the purpose of producing purified water through reverse osmosis filtration.

7.PHRegulating system, function: throughPHAdjust to7Left and right, remove from the waterCO2 Ensure the quality of the produced water. Reverse osmosis can ensure the quality of the produced water and makeEDIThe quality of the produced water is more stable and the service life of the nuclear energy resin is longer.

8.Purified water tank, function: Store the secondary reverse osmosis product water and provide water source for the terminal purified water usage point.

9.System, function: Used for cleaning the purified water pipeline and the purified water tank.

10.Ultraviolet device, function: Kill residues in water and ensure the quality of the effluent.

11.The function of the microfilter is to filter out particles killed by ultraviolet rays and other particles.

12.Purified water booster pump,Function: To deliver pure water to water usage points.

Vi. General Table of Technical Parameters for Pharmaceutical Purified Water Equipment System